Introduction the root of saussurea lappa asteraceae known as costus is used in traditional medicine of many countries in the reatment of several diseases and ailments 1. Evaluation of antiresistant activity of auklandia saussurea lappa root against some. Out of 125 species about 47 species are reported in india of which saussurea lappa is reputed for the medicinal properties of its roots. Isolation and purification were carried out by silica gel, sephadex lh20 and rp18 column chromatography. Data are mean from 22 migraine patients and 10 controls and 10 drug treated patients. Effect of costunolide a plant product of saussurea lappa on. Saussurea costus is a classified as a perennial, with a typical growth of 12 m 3. Plants and mushrooms are used for medicinal purposes and the screening of molecules possessing biological activities. Genome wide transcriptome profiling reveals differential gene. Their structures were determined on the basis of spectral data including 1d and 2d nmr and hreims. Sesquiterpenoids from costus root oil saussurea lappa clarke. Saussurea is especially prized in tibetan and traditional chinese medicine and is among the most sacred plants in india, where it is used to pay homage to the goddess nanda devi. It is popularly known as kuth root or costus and used in various traditional system of medicine for its antiulcer, anticonvulsant, anticancer, hepatoprotective, anti. To seed rates and nitrogenfertilizer raj vir singh and s.
The stem bark and root of flacourtria romantchi were collected from road side location of agra, district agra, uttar pradesh, india. Saussurea lappa induces g2growth arrest and apoptosis in. The ulcer index in the saussurea lappa root treated animals was found to be significantly less in all the models compared to standard drug treated cases. Saussurea costus, commonly known as costus or kuth, is a species of thistle in the genus saussurea native to india. Although the overall phylogenetic framework among the species of saussurea in korea is lacking, s. Saussurea lappa root 400mgkg showed maximum inhibition of gastric acid, free acid and total acid to 53. Nanda medicinal plants company is registered with ministry of environment and forest for cultivation of threaten sp. The family has 300 species globally in which approximately 61 species exist in india 2. Saussurea lappa clarke compositae is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous indian systems of medicine. Saussurea costus common name is costus and local name is kuth. The isolation of four novel acylated flavonoid glycosides from the roots of saussurea lappa and their identification using a combination of 1d and 2d nmr and mass spectrometry is described. Antioxidants free fulltext saussurea lappa ethanolic.
Madhuri k, elango k and ponnusankar s, saussurea lappa kuth root. Clarke asteraceae introduction saussurea dc is a large genus of annual, biennial or perennial herbs distributed in the temperate regions of asia, europe and north america. Acylated flavone glycosides from the roots of saussurea lappa. Gas chromatographymass spectrometry profiling of the. Here, we report on the chemistry of the ethanol and water extracts of s. Saussurea lappa is costus plant from the family of compositae.
Pharmacologic s anticancer, antioxidant, antiinflammatory, 2. Colony road, bulandshahr 203 001, india abstract a field experiment was carried out. The root of ficus bengallensis was collected from the campus of nims university jaipur rajasthan, india. Comparative acute toxicity studies of selected indigenous. Conservation status and therapeutic potential of saussurea lappa. Hence, this study explored, for the first time, the possible beneficial effects of s. It founds in himalyan region and the root is widely used for various diseases due to its broad medicinal property. Lipsch belonging to family asteraceae table 1, commonly known. Subsequently, a new crystalline lactonesaussurea lactone c15h20o2rao and verma, 1951 and costunolide were isolated from costus saussurea lappa root oil rao. Saussurea lappa sl has been used as a traditional herbal medicine to treat abdominal pain and tenesmus, and has been suggested to possess various biological activities, including antitumor, antiulcer, antiinflammatory, antiviral, and cardiotonic activities. Identification of the genes and transcriptional regulation of costunolide biosynthesis pathway in s. Our online converter of esri shapefile format to geospatial pdf format shp to pdf is fast and easy to use tool for both individual and batch conversions. The chemical structures of constituents were elucidated on the basis of spectral data. Saussurea costus synonymous with saussurea lappa, locally known as kuthis a robust perennial herb of the western himalayas, distributed in pakistan and india.
Saussurea lappa, biological active compounds, medicinal uses, potential. It is mainly regulated by hepatic stellate cells, which acquire a fibrogenic character in response to oxidant. Costus, or kuth, with the scientific name saussurea costus or saussurea lappa, is a thistle species that is native to south asia, especially in jammu, kashmir, the himalayas, the kishenganga valley, and the western ghats this gorgeous perennial plant is characterized by purple floret heads and long lyrate leaves. Hye in lee, jiae lee, donghyun hwang, gongrak lee, narae kim, minjeong kwon, hana lee, donglan piao, hyun jin kim, nam young kim, han sung kim, eun kyoung seo, dongmin kang, and. Many of these compounds have been found to possess a wide range of biological activity such as anticancer, antiinflammatory, antihepatotoxic, antiviral, etc. A new sesquiterpene lactone from the roots of saussurea lappa.
Suhexiang wan essential oil alleviates amyloid beta induced. A single plant or mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on experimental conditions, but the reason behind this dichotomy remains obscure. The chemical constituents were isolated from the roots of saussurea lappa. Subsequently, a new crystalline lactone saussurea lactone c15h20o2rao and verma, 1951 and costunolide were isolated from costus saussurea lappa root oil rao. Prophylactic effect of cousts saussurea lappa against liver injury. Research article open access saussurea lappa extract. Structureanticancer activity study the dried roots of saussurea lappa, called costus roots, are used in the. Differential enhancement of leukaemia cell differentiation. The efficacy of herbal auklandia costus saussurea lappa s. Comparison of volatile aroma components from saussurea lappa.
Unit a 125, patparganj industrial area delhi 110092 unit b 476, patparganj industrial area, delhi 110092. The effect of sl on breast cancer metastasis, however, is unknown. To study the chemical constituents in roots of saussurea lappa. The species is endemic to a geographically limited part of the himalayas, and grows on moist slopes at altitudes of. Santamarin, a sesquiterpene lactone isolated from saussurea lappa, represses lpsinduced inflammatory responses via expression of heme oxygenase1 in murine macrophage cells. Presence of cholinergic and calcium antagonist constituents in saussurea lappa explains its use in constipation and spasm. Request pdf a new sesquiterpene lactone from the roots of saussurea lappa. Saussurea lappa, indigenous medicine, costunolide, antiic uses. As an effective expectorant, it helps to treat asthma by making breathing easier, clearing and relaxing bronchiole. Acylated flavone glycosides from the roots of saussurea. Triamcinolone acetonide ta is an extensively used glucocorticoid. Immunomodulatory properties of plants and mushrooms. You will be redirected to the full text document in the repository in a few seconds, if not click here.
Costunolides, an important sesquiterpene lactone stl isolated from saussurea lappa, are the major pharmaceutical ingredient of various drug formulations. Alantolactone from saussurea lappa exerts antiinflammatory effects by inhibiting chemokine production and stat1 phosphorylation in tnf and ifninduced in hacat cells hye. We present here a large body of experimental data showing that water extracts of plants. Microsatellite markers for saussurea polylepis asteraceae. Suhexiang wan shxw, a traditional chinese medicine, has been used orally for the treatment of seizures, infantile convulsions and stroke. With kernelex and kstub822 you can install it up to version 2.
However, the cites management authority of india is of the view that a more. View enhanced pdf access article on wiley online library html view. Essential oils extracted from the root have been used in traditional medicine and in perfumes since ancient times. Negi department of agronomy, cotton research station, d. Pdf xchange viewer is a fast and free pdf reader with kernelex you can install it up to version 2. The effects of subinhibitory concentrations of costus oil on. Costus root essential oil, absolute and concrete saussurea lappa clarke oils, costus saussurea lappa root oil spiral flag oil history. Choi et al 2005 inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Jan 04, 2012 saussurea lappa has been used in chinese traditional medicine for the treatment of abdominal pain, tenesmus, nausea, and cancer. Saussurea lappa, costus, antibacterial activity, chemical composition, ir and hplc analysis.
Effects of saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferongamma ifngamma. Its roots are used especially in siddha for the medicinal purposes 17. It is popularly known as kuth root or costus and used in various traditional system of medicine for its antiulcer, anticonvulsant, anticancer, hepatoprotective, antiarthritic, antiviral activities. Despite significant progress in phytochemical and biological analyses of s.
Novel and therapeutic effect of caffeic acid and caffeic acid. I basically need to understand how browsers support pdf viewing and which ones do. The species is endemic to a geographically limited part of the himalayas, and grows on moist slopes at altitudes of 26004000 m. Kuth saussurea lappa cultivation in the cold desert environment of the lahaul valley, northwestern himalaya, india. The costus saussurea lappa is a wellknown medicinal plant that has been widely used in the traditional medicines in many asian countries. Pdf saussurea lappa clarke compositae is a traditionally known and potent plant which is well considered for its medicinal uses in different. Costus saussurea lappa, saussurea costus is an herbaceous plant whose roots are used for traditional medicine. Cites listed medicinal plants of india an identification manual. Effect of dehydrocostus lactone isolated from the roots of.
It has long lyrate leaves and heads of purple florets. Phytochemistry of saussurea lappa after thorough literature survey revealed various varied and copious metabolites such as sesquiterpenes, flavonoids, phytosterols, lignans, terpenes. Viewer will automatically bundle the resources directory in the toplevel skia directory, and will bundle an skps directory if also placed in the skia directory. Both saussurea lappa and saussurea costus are threatened due to the unregulated collection and illegal trade of the medicinal plant. Conservation status and therapeutic potential of saussurea. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. Bdependent mmp9 expression in mcf7 breast cancer cells 25 may 2014 bmc complementary and alternative medicine, vol. An international journal of research in ayush and allied. It is a long erect herb found mostly in northern mountainous regions of pakistan and india gupta et al. Since the ancient time, oil from the roots of plant has found uses in traditional medicine.
Introduction saussurea lappa is a potential herb belonging to family asteraceae table 1. Advances in transcriptome sequencing provide fast, costeffective and reliable approach to generate large expression datasets especially suitable for nonmodel species to identify putative genes. Dehydrocostus lactone suppresses osteoclast differentiation. International science congress association 55 effect of costunolide a plant product of saussurea lappa on feeding behaviour of papilio demoleus l. We assure you of fresh raw herbs directly procured form authentic and reputed dealers of the herbs. The costus root is about a human fingers size with a woody part that is. Saussurea is a genus of about 300 species of flowering plants in the thistle tribe within the daisy family, native to cool temperate and arctic regions of asia, europe, and north america, with the highest diversity in alpine habitats in the himalaya and central asia. Kuth saussurea lappa is an herb belonging to the family asteraceae. Saussurea lappa is a famous medicinal plant with many biologically active compounds. Converter also supports more than 90 others vector and rasters giscad formats and more than 3 000 coordinate reference systems. Reason that im asking this is im building a pdf gallery viewer. Saussurea lappa inhibits the growth, acid production, adhesion and water insoluble glucan synthesis of streptococcus mutans. It has simple, alternate, opposite or whorled leaves. Saussurea lappa is a traditionally wellknown plant for its medicinal uses in different indigenous systems of medicine.
In the modern days, the essential oil of the roots is used for enhancing the scent of certain personal care products and alcoholic drinks, as well as for treating colds, bacterial infection, and digestive. Alantolactone from saussurea lappa exerts antiinflammatory. Kushta saussurea lappa benefits, usage, dose, side effects kushta or indian costus root is a famous ayurvedic herb used in treating gout, skin diseases, respiratory disorders etc. Sesquiterpenoids from costus root oil saussurea lappa. Common names include sawwort and snow lotus, the latter used for a number of high altitude species in central asia. Original article metabolic transformation of breast cancer in a mcf7 xenograft mouse model and inhibitory effect of volatile oil from saussurea. Kuth saussurea lappa cultivation in the cold desert environment. It is widely used in the treatment of asthma, ulcer, stomach problems and. Micropropagation through apical shoot explants and.
Jeong et al 2002 costunolide, a sesquiterpene lactone from saussurea lappa, inhibits the vegfr kdrflk1 signaling pathway. If the coordinate system of your input data is not present or. Saussurea lappa roots have been widely used in chronic gastritis, rheumatoid arthritis, asthma and bronchitis in traditional medicine and in inflammationrelated diseases 22. Based on article 16d1, article 16f and article 16h of directive 200183ec as amended traditional use final herbal substances binomial scientific name of the plant, including plant part arctium lappa. One of the founders of modern linguistics linguistics, scientific study of language, covering the structure morphology and syntax. Papilionidae larvae srinivasa rao vattikonda, nageswara rao amanchi and sabita raja sangam. It was found that both species are really separated from each. The roots possess carminative, analgesic, anthelmintic and. Access full text pdf title studying the role of art discourse in displacement of signs and change of their semantic function a case study of photo collection of 18 frames with the womancentered perspective. Saussurea costus clarke compositae synonymous with saussurea lappa, locally known as kuth, is a robust perennial herb of the western himalayas.
The hexane extract of saussurea lappa and its active. Dehydrocostus lactone suppresses osteoclast differentiation by regulating nfatc1 and inhibits osteoclast activation through modulating migration and lysosome function. Study on chemical constituents from roots of saussurea lappa. The root of saussurea lappa was collected from general herbal market, jaipur rajasthan, india.
It is endangered species which is controlled by the ministry of environment and forest. We further tested their antimicrobial activities against. Effect of costunolide a plant product of saussurea lappa. Saussurea costus is effective as a treatment for cough, asthma, bronchitis and cholera. Saussurea lappa extract suppresses tpainduced cell invasion via inhibition of nf. On ios the viewer provides basic touch functionality. Database of genomic structural variation dbvar genbank.
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